Comment on "Reflex epileptic mechanisms in humans: Lessons about natural ictogenesis" by Peter Wolf

We readwith great interest the review by PeterWolf who discusses extensively the most known reflex epileptic traits and the related hypotheses on their ictogenesis [1]. In particular, he presents the contribution provided by advanced neuroimaging techniques, especially ictal and interictal EEG-fMRI studies. Among the reflex epileptic traits, eye closure sensitivity (ECS) has been considered and discussed in light of a recent study by our group [2] in patients with Jeavons syndrome [or eyelid myoclonia with absences (EMA), which represents the archetypal of ECS]. Since several questions have been raised by Prof. Wolf in reference to our findings, we would like to take the opportunity to try to answer some of the raised questions and to better clarify our point of view about the ECS phenomenon.