Distinctive clinical and dermoscopic features of BRAFp.V600K mutated melanomas.

dermoscopic criteria associated with BRAF and NRAS mutation status in primary cutaneous melanoma have been recently analyzed by Pozzobon et al. in an interesting study published in your journal. The authors found out that peppering pattern was significantly increased among BRAF mutant melanoma, being present in the 68% of their cases series, with OR 1.68 (CI 95%1.089-2.581, p=0.015).1 The intend of this letter is to underline the dermoscopic features and the distinctive clinical features of BRAF p.V600K melanoma (the second most common BRAF V600 mutation detected in 5 to 30% of cases), that might be slightly different from from BRAF p.V600E melanoma.