Data di Pubblicazione:
1993
Citazione:
REVERSING OF CHLORAMBUCIL RESISTANCE BY ETHACRYNIC-ACID IN A B-CELL PATIENT / Petrini, M; Conte, Angela; Caracciolo, F; Sabbatini, Anna Maria Teresa; Grassi, B; Ronca, G.. - In: BRITISH JOURNAL OF HAEMATOLOGY. - ISSN 0007-1048. - STAMPA. - 85:(1993), pp. 409-410. [10.1111/j.1365-2141.1993.tb03187.x]
Abstract:
We evaluated the reversing activity of ethacrynic acid in a B-CLL patient resistant to chlorambucil. The glutathione S-transferase (GST) activity, measured in peripheral blood lymphocytes, resulted extremely elevated. Ethacrynic acid, at pharmacological concentrations, partially reversed chlorambucil resistance and this result appeared related to the increased GST levels.
Tipologia CRIS:
Articolo su rivista
Keywords:
ethacrynic acid; chlorambucil resistance; multidrug resistance
Elenco autori:
Petrini, M; Conte, Angela; Caracciolo, F; Sabbatini, Anna Maria Teresa; Grassi, B; Ronca, G.
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