Plasma glutathione level in chronic headache drug abuser patients

Plasma reduced glutathione (GSH) seems to reflect liver GSH content, we have assessed plasma GSH in patients with chronic headaches. We found a significant lower plasma GSH concentration was found with respect to controls. We teste a administartion of GSH IV and found that.v. GSH free plasma cysteine was 12 fold higher than in basal condition and all the pattern of plasma thiol groups was modified. This work suggests a possible protective effect of GSH administration in Chronic Headache patients.