Data di Pubblicazione:
2010
Citazione:
The discovery of novel, highly potent inhibitors of BRAF / Niculescu Duvaz, I.; Menard, D; Niculescu Duvaz, D.; Zambon, Alfonso; Davies, L; Preece, N.; Kirk, R.; Whittaker, S.; Marais, R.; Springer, C.. - In: EUROPEAN JOURNAL OF CANCER. - ISSN 0959-8049. - 8:7(2010), pp. 139-139. [10.1016/S1359-6349(10)72148-0]
Abstract:
We describe the synthesis and optimisation of a series of new inhibitors of BRAF, a kinase whose mutant form (V600E) is implicated in several
types of cancer, with particularly high frequency in melanoma. We designed and synthesised type II inhibitors interacting with the inactive conformation
of the V600EBRAF.
Tipologia CRIS:
Abstract in Atti di Convegno
Elenco autori:
Niculescu Duvaz, I.; Menard, D; Niculescu Duvaz, D.; Zambon, Alfonso; Davies, L; Preece, N.; Kirk, R.; Whittaker, S.; Marais, R.; Springer, C.
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