Angiopoietin-2 acts as a survival factor for chronic lymphocytic leukemia B cells throughout Tie-2 receptor engagement

Articolo

Data di Pubblicazione:

2018

Citazione:

Angiopoietin-2 acts as a survival factor for chronic lymphocytic leukemia B cells throughout Tie-2 receptor engagement / Maffei, Rossana; Fiorcari, Stefania; Martinelli, Silvia; Guarnotta, Carla; Benatti, Stefania; Belmonte, Beatrice; Potenza, Leonardo; Luppi, Mario; Marasca, Roberto. - In: HEMATOLOGICAL ONCOLOGY. - ISSN 0278-0232. - 36:1(2018), pp. 372-375. [10.1002/hon.2448]

Abstract:

we demonstrated that: (i) CLL cells expressed Tie-2 receptor both in peripheral blood and in lymph nodes; (ii) Ang2 may interact with Tie-2 in CLL mediating a survival signal throughout PI3K-AKT signalling, and (iii) the interruption of Ang2/Tie-2 signalling may be effective in CLL.

Tipologia CRIS:

Articolo su rivista

Keywords:

Hematology; Oncology; Cancer Research

Elenco autori: