INFLUENCE OF IDAZOXAN ON THE DOPAMINE D(2) RECEPTOR AGONIST-INDUCED BEHAVIORAL-EFFECTS IN RATS

The behavioural effects in rats of the dopamine D2 receptor agonists. lisuride, B-HT 920 and SND 919. were variously influenced by pre-treatment with the selective alpha2-adrenoceptor antagonist, idazoxan (2 mg/kg), depending on the nature of the effect in question and the doses of agonist employed. The influence of idazoxan on drug-induced stretching-yawning, penile erection, sedation, stereotyped behaviour, aggressiveness and mounting is described and tentatively interpreted in neurochemical terms, account being taken of the activity of respective alpha2-adrenoceptor antagonist and dopamine receptor agonists used, at alpha2-adrenoceptors and at different dopamine D2 receptor subtypes, pre- and postsynaptically located.