Assessment of submicroscopic genetic lesions by single nucleotide polymorphism arrays in a child with acute myeloid leukemia and FLT3-internal tandem duplication
Articolo
Data di Pubblicazione:
2006
Citazione:
Assessment of submicroscopic genetic lesions by single nucleotide polymorphism arrays in a child with acute myeloid leukemia and FLT3-internal tandem duplication / S., Bungaro; M., Raghavan; M. G., Delloro; Paolucci, Paolo; B. D., Young; A., Biondi; G., Cazzaniga. - In: HAEMATOLOGICA. - ISSN 0390-6078. - STAMPA. - 91:7(2006), pp. 998-1000.
Abstract:
The same FLT3-internal tandem duplication (ITD) positive clone was detected at diagnosis and relapse, but not at birth, in a child with M1 acute myeloid leukemia. Single nucleotide polymorphism arrays demonstrated that chromosome 13 acquired uniparental disomy, in association with del(9q), represented a progressive event in the course of the disease, and it was responsible for the homozygous FLT3-ITD at relapse.
Tipologia CRIS:
Articolo su rivista
Keywords:
childhood AML; RQ-PCR; SNP array; FLT3-ITD; prenatal.
Elenco autori:
S., Bungaro; M., Raghavan; M. G., Delloro; Paolucci, Paolo; B. D., Young; A., Biondi; G., Cazzaniga
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