Vigabatrin and psychosis

Use of Vigabatrin (GVG) in the treatment of severe refractory epilepsy has been associated with sporadic development of psychosis. Two women with drug-resistant complex partial seizures and no previous history of psychosis developed a psychotic state following GVG treatment, during which they did not present seizures and EEG was improved or normal. The mechanism of this behaviour change is unclear as is the nature of the association between GVG treatment and psychosis.