Relationship between growth inhibition and mitochondrial function in petite-negative yeasts. II Effects of central nervous system drugs upon pathogenic and non- pathogenic Candida species.

Six nervous system drugs which inhibited vegetative reproduction of Saccharomyces cerevisiae arrested also mitotic division of Candida utilis, C. albicans and C. tropicalis. Chlorpromazine and chlorpheniramine which proved to be the most effective, affected respiration and cytochrome biosynthesis. Electrophoretic bands with MW 100K were faint in silver-stained electrophoregrams of proteins from cells grown in the presence of a sub-inhibitory concentration of chlorpromazine.