Age-related variations in relative abundance of alternative spliced D2 receptor mRNAs in brain areas of two rat strains

Age-related reduction in the steady-state levels of messenger RNA for D2javax.xml.bind.JAXBElement@698be68c and D2javax.xml.bind.JAXBElement@3b75e9a8, the alternatively spliced form of dopamine D2 receptors, was observed in different rat brain areas using the sensitive reserve transcription (RT)-polymerase chain reaction (PCR) technique. In both Sprague-Dawley and Wistar aged rats, the decrease was more pronounced in the D2javax.xml.bind.JAXBElement@6e2a8528 isoform mRNA thus leading to a changed ratio in striatum as well as in the hyppocampus. © 1992.