A human dopamine transporter cDNA predicts reduced glycosylation, displays a novel repetitive element and provides racially-dimorphic TaqI RFLPs
Articolo
Data di Pubblicazione:
1992
Citazione:
A human dopamine transporter cDNA predicts reduced glycosylation, displays a novel repetitive element and provides racially-dimorphic TaqI RFLPs / Vandenbergh, D J; Persico, A M; Uhl, G R. - In: MOLECULAR BRAIN RESEARCH. - ISSN 0169-328X. - 15:1-2(1992), pp. 161-166. [10.1016/0169-328X(92)90165-6]
Abstract:
We describe a cDNA for the human dopamine transporter, which has been implicated in several human disorders linked to dopaminergic function. The cDNA predicts reduced glycosylation of the protein with respect to the rat transporter, as well as a novel repetitive element in the 3' untranslated region of the cDNA. A TaqI RFLP is also reported that shows a race-specific difference in allelic frequencies.
Tipologia CRIS:
Articolo su rivista
Keywords:
Blotting; Southern; Carrier Proteins; Cloning; Molecular; Continental Population Groups; DNA; Deoxyribonucleases; Type II Site-Specific; Dopamine Plasma Membrane Transport Proteins; Glycosylation; Humans; In Situ Hybridization; Molecular Sequence Data; Sequence Alignment; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Polymorphism; Restriction Fragment Length; Repetitive Sequences; Nucleic Acid
Elenco autori:
Vandenbergh, D J; Persico, A M; Uhl, G R
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