Data di Pubblicazione:
2002
Citazione:
Monitoring levels of preservative sensitivity in Europe - A 10-year overview (1991-2000) / J. D., Wilkinson; S., Shaw; K. E., Andersen; F. M., Brandao; D. P., Bruynzeel; M., Bruze; J. M., G.; T. L., Diepgen; G., Ducombs; P. J., Frosch; A., Goossens; J. M., Lachappelle; A., Lahti; T., Menne; Seidenari, Stefania; A., Tosti; J. E., Wahlberg. - In: CONTACT DERMATITIS. - ISSN 0105-1873. - STAMPA. - 46:4(2002), pp. 207-210. [10.1034/j.1600-0536.2002.460404.x]
Abstract:
A 10-year multicentre analysis of the frequency of sensitivity to common preservatives collected in 16 centres in 11 countries has shown stable but persisting high levels of sensitivity to formaldehyde and 5-chloro-2-methyl-4-isothiazolin-3-one + 2-methyl-4-isothiazolin-3-one (MCI/MI). It has also revealed a significant increase in the level of reactivity to methyldibromoglutaronitrile (MDBGN) from 0.7% in 1991 to 3.5% in 2000. The current high level of sensitivity to MDBGN requires an urgent safety re-evaluation and risk assessment update along with consideration of immediate lowering of use concentrations, especially in leave-on products.
Tipologia CRIS:
Articolo su rivista
Keywords:
patch test; contact sensitization; preservative; cosmetics
Elenco autori:
J. D., Wilkinson; S., Shaw; K. E., Andersen; F. M., Brandao; D. P., Bruynzeel; M., Bruze; J. M., G.; T. L., Diepgen; G., Ducombs; P. J., Frosch; A., Goossens; J. M., Lachappelle; A., Lahti; T., Menne; Seidenari, Stefania; A., Tosti; J. E., Wahlberg
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