Griffonia simplicifolia negatively affects sexual behavior in female rats

At present Griffonia simplicifolia is used in food supplement aimed to treat mood disorders as well asto reduce food intake and body weight. The plant has gained increasing interest for its high content in5-hydroxy-l-tryptophan (5-HTP) particularly in the seed. The present study was designed to evaluatethe influence of a seed extract of the plant, dosed at 25, 50 and 100 mg/kg, on the sexual behavior ofovariectomized hormone-primed rats after acute and subchronic treatment. The single administrationof G. simplicifolia significantly reduced lordosis response and increased rejection behavior in female ratstreated with the highest dose while it did not influence proceptive behaviors. On the other hand the subchronicadministration of the extract significantly reduced proceptivity but not receptivity, and increasedrejection behavior. All the tested dosages were able to markedly decrease food intake and body weightafter a 9-day treatment. Taken together the present results, possibly ascribed to increased levels of 5-hydroxytryptamine (5-HT) in the brain, suggest a cautious administration of the plant extract owing toits negative influence on female sexual behavior.