MOLECULAR REQUIREMENTS OF THE ACTIVE SITESOF THE CHOLINERGIC RECEPTORSXVI (x) - Synthesis qnd cholinergic activity ol 2- or 5-alkyl or 5-phenyl--4-methyl-3-oxo-1 -dimethylaminomethylcy clopentane methiodide.

In order to study the cholinergic receptor through affinitychromatography, some derivatives ol deoxamuscarone (1 a) incorporating alkyl and phenyl substituents at the positions 2 and 5 were synthesizedas model compounds. However, the sharp drop in activity and the lack of discrimination between nicotinic and muicarinic receptors exhibited by thecompounds discourage their further development as affinity reagents