Increase degradation of cholesterol via the alternate pathway of bile acid biosynthesis in primary hypercholesterolemia.

Priamry hyeprcholesterolemai associates with increased rates of cholesterol 27 hydroxylation which normalizes with statin treatment. the correlation between plasma cholesterol levels and 27 hydroxylation support the view that the latter may act as a compensatory mechanism in a condition of larger plasma cholesterol pool. A regulatory roel for uclear receptors seems reasonable.These dta may encourage novel pharmacplogical approaches for the managment of hypercholesterolemia and prevention of atherosclerosis