Pharmacokinetics of tia profenic acid in headache attacks - a preliminary report

This preliminary study examined the pharmacokinetics of 300 mg of tiaprofenic acid, in single oral dose, in 7 migraine patients during and out of migraine attacks. Plasma concentration of tiaprofenic acid was determined by HPLC analysis. The absorption phase did not differe between in and out migraine attacks. also other pharmacokinetic parameters evaluated were not affected by headache attacks as well. We conclude that tiaprofenic acid absorption and metabolism are not affected by migraine attacks.