FOXP1 and TP63 involvement in the progression of myelodysplastic syndrome with 5q- and additional cytogenetic abnormalities
Articolo
Data di Pubblicazione:
2014
Citazione:
FOXP1 and TP63 involvement in the progression of myelodysplastic syndrome with 5q- and additional cytogenetic abnormalities / L'Abbate, Alberto; Lo Cunsolo, Crocifissa; Macrì, Ettore; Iuzzolino, Paolo; Mecucci, Cristina; Doglioni, Claudio; Coco, Michelina; Muscarella, Lucia Anna; Salati, Simona; Tagliafico, Enrico; Minoia, Carla; De Tullio, Giacoma; Guarini, Attilio; Testoni, Nicoletta; Agostinelli, Claudio; Storlazzi, Clelia Tiziana. - In: BMC CANCER. - ISSN 1471-2407. - ELETTRONICO. - 14:1(2014), pp. 1-7. [10.1186/1471-2407-14-396]
Abstract:
The progression of low-risk del(5q) myelodysplastic syndrome to acute myeloid leukemia is increased when associated with mutations of TP53, or with additional chromosomal abnormalities. However, to date the prognostic impact and molecular consequences of these rearrangements were poorly investigated. Single additional alterations to del(5q) by balanced chromosome rearrangements were rarely found in myelodysplasia. In particular, balanced alterations involving TP63 and FOXP1 genes were never reported in the literature.
Tipologia CRIS:
Articolo su rivista
Keywords:
Aged; Chromosome Aberrations; Chromosomes, Human, Pair 3; Chromosomes, Human, Pair 5; Female; Forkhead Transcription Factors; Humans; In Situ Hybridization, Fluorescence; Myelodysplastic Syndromes; Prognosis; Repressor Proteins; Transcription Factors; Translocation, Genetic; Tumor Suppressor Proteins; Disease Progression
Elenco autori:
L'Abbate, Alberto; Lo Cunsolo, Crocifissa; Macrì, Ettore; Iuzzolino, Paolo; Mecucci, Cristina; Doglioni, Claudio; Coco, Michelina; Muscarella, Lucia Anna; Salati, Simona; Tagliafico, Enrico; Minoia, Carla; De Tullio, Giacoma; Guarini, Attilio; Testoni, Nicoletta; Agostinelli, Claudio; Storlazzi, Clelia Tiziana
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