Tumor VEGF expression correlates with tumor stage and identifies prognostically different groups in patients with clear cell renal cell carcinoma
Articolo
Data di Pubblicazione:
2015
Citazione:
Tumor VEGF expression correlates with tumor stage and identifies prognostically different groups in patients with clear cell renal cell carcinoma / Minardi, D.; Santoni, M.; Lucarini, G.; Mazzucchelli, R.; Burattini, L.; Conti, A.; Bianconi, M.; Scartozzi, M.; Milanese, G.; Di Primio, R.; Montironi, R.; Cascinu, Stefano; Muzzonigro, G.. - In: UROLOGIC ONCOLOGY. - ISSN 1078-1439. - ELETTRONICO. - 33:3(2015), pp. 1-7. [10.1016/j.urolonc.2014.06.014]
Abstract:
Objectives: Vascular endothelialgrowthfactor(VEGF)isapotentinduceroftumorangiogenesisandrepresentsthekeyelementinthe
pathogenesis ofclearcellrenalcellcarcinoma(ccRCC).TheaimofthisstudywastoinvestigatetheuseoftumorVEGFexpressionasa
parameter toidentifytumorstageandprognosticallydifferentpatientgroups.
Methods andmaterials: We retrospectivelycollectedclinicaldataof137patientstreatedwithpartialorradicalnephrectomyatour
institutions fororgan-confined, locallyadvanced,andmetastaticccRCCsbetween1984and2013.TumorcellVEGFimmunohistochemical
expression wascomparedwithpathologicalandclinicalfeaturesincludingage,sex,tumorstage,andFuhrmangrade.ComparisonofVEGF
expression levelsbetweentumorstageswasperformedviaKruskal-Wallisnonparametrictest.SurvivalanalysiswasconductedviaKaplan-
Meier product-limitmethod,andMantel-Haenszellog-ranktestwasemployedtocomparesurvivalamonggroups.
Results: Medianageatdiagnosiswas61years(range:33–85y).TumorstagewaspT1N0M0in67patients(49%),pT2N0M0in5(4%),and
pT3N0M0in25(18%),while40patients(29%)hadmetastatictumorsat diagnosis.FuhrmannucleargradewasG1in22patients(16%),G2in60
(44%),G3in33(24%),G4in13patients(9%),andunknownin9patients. TumorVEGFwasdifferentiallyexpressedamongdifferentstages
(P o 0.001)andinlow(G1–2)andhigh(G3–4) Fuhrmangradetumors(P o 0.001).Nosignificantdifferenceswerefoundwhenstratifyingbysex
(P ¼ 0.06)orage(P ¼ 0.29).Medianoverallsurvival(OS)frompartialorradicalnephrectomywas161months(range:1–366).Weobserveda
significantly longerOSinpatientswithlow(o25%)vs.high(425%)VEGFexpressionlevels(medianOS206vs.65mo, P o 0.001).
Conclusions: OurdatashowthattumorcellVEGFexpressionissignificantly associatedwithtumorstageandFuhrmangradeandis
able topredictpatientoutcome,suggestingapotentialuseofthisparameter inidentifyingprognosticallydifferentpatientswithccRCC.
Tipologia CRIS:
Articolo su rivista
Keywords:
Vascular endothelial growth factor; Clear cell rena lcell carcinoma; Tumor stage; Tumor grade; Overall survival
Elenco autori:
Minardi, D.; Santoni, M.; Lucarini, G.; Mazzucchelli, R.; Burattini, L.; Conti, A.; Bianconi, M.; Scartozzi, M.; Milanese, G.; Di Primio, R.; Montironi, R.; Cascinu, Stefano; Muzzonigro, G.
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