Cell Death Pathways in an Unconventional Invertebrate Model

Programmed cell death (including apoptosis and autophagy-mediated cell death) is a fundamental feature of many important biological processes devoted to the maintenance of the body's homeostasis. Numerous research studies on programmed cell death included well-established invertebrate models like Drosophila melanogaster and Caenorhabditis elegans, and their contribution to the present knowledge on cell death was decisive. Despite this, several questions remain, especially in the relationships existing between the diverse modalities of cell death, asking for further experiments in different models. Here, we describe the prodeath effects and the pathways activated by the mitochondria-targeting drugs 2-deoxy-. d-ribose, sodium nitroprusside, or oligomycin A in the IPLB-LdFB cell line derived from the unconventional insect model Lymantria dispar.