Loss of self-regulation in interstitial fluid dynamics of septic patients, and oedema development patterns

Attempts to effectively intervene on sepsis mechanisms by correcting the dysfunction and the pathological activation of microcirculation-and, therefore, of the endothelium-represent the most fascinating challenge for physicians and researchers dealing with these patients. However, to date there is no evidence that specific therapeutic strategies aimed at controlling micro-vascular endothelium may, in patients suffering septic shock, provide clinical benefits and increased survival probability. As for oedema and sepsis, the news is even worse: We know that the formation of oedema is a constant in patients with sepsis, we know that the development of oedema can cause the deterioration of organ functioning due to deficient perfusion and cellular oxygenation and we know that, unfortunately, today there is no effective drug nor winning strategy.