cGMP-compliant transportation conditions for a prompt therapeutic use of marrow mesenchymal stromal/stem cells
Chapter
Publication Date:
2015
Short description:
cGMP-compliant transportation conditions for a prompt therapeutic use of marrow mesenchymal stromal/stem cells / Veronesi, E., Burns, J.P.J.S., Murgia, A., Candini, O., Rasini, V., Mastrolia, I., Catani, F., Paolucci, P., Dominici, M. (METHODS IN MOLECULAR BIOLOGY). - In: Methods in Molecular Biology / Elena Veronesi, Jorge Sans Burns, Alba Murgia, Olivia Candini, Valeria Rasini, Ilenia Mastrolia, Fabio Catani, Paolo Paolucci, Massimo Dominici. - STAMPA. - [s.l] : Humana Press Inc., 2015. - pp. 109-122 [10.1007/7651_2014_105]
abstract:
We recently described conditions for safe 18-h manufacturer-to-patient transportation of freshly harvested hBM-MSC expanded under cGMP protocols using human platelet lysate (hPL), that allowed prompt use as an advanced therapeutic medicinal product. Here we outline important considerations when comparing different transportation conditions, highlighting that although cell transportation may involve a reduction in viability, this did not undermine the ultimate bone-forming regenerative potential of the cGMP-hBM-MSC population.
Iris type:
Capitolo/Saggio
Keywords:
Bone regeneration; CGMP-compliant; Fresh; MSC; Platelet lysates; Saline solution; Transportation; Cell Culture Techniques; Humans; Mesenchymal Stromal Cells; Specimen Handling; Guideline Adherence; Transportation; Molecular Biology; Genetics; Medicine (all)
List of contributors:
Veronesi, Elena; Burns, Jorge Phillip Joaquin Sans; Murgia, Alba; Candini, Olivia; Rasini, Valeria; Mastrolia, Ilenia; Catani, Fabio; Paolucci, Paolo; Dominici, Massimo
Book title:
Methods in Molecular Biology
Published in: