BRAIN-SEROTONIN BINDING-CAPACITY, ANALGESIA AND DRUG SERUM LEVELS AFTER ACUTE TREATMENT WITH PHENAZONE IN RATS
Academic Article
Publication Date:
1992
Short description:
BRAIN-SEROTONIN BINDING-CAPACITY, ANALGESIA AND DRUG SERUM LEVELS AFTER ACUTE TREATMENT WITH PHENAZONE IN RATS / Pini, Luigi Alberto; Vitale, Giovanni; Sandrini, Maurizio. - In: PHARMACOLOGICAL RESEARCH. - ISSN 1043-6618. - STAMPA. - 25:(1992), pp. 258-259. [10.1016/1043-6618(92)90392-O]
abstract:
Phenazone induces analgesia in the hot-plate test and decreases the number of cortical and pontine 5-HT binding sites A pre-treatment with PCPA prevents both the analgesic effect and the reduction of 5-HT binding sites caused by phenazone. These data suggest that the brain serotonin system may play a role in phenazone-induced antinociception.
Iris type:
Articolo su rivista
Keywords:
SEROTONIN RECEPTORS; PHENAZONE; ANALGESIA
List of contributors:
Pini, Luigi Alberto; Vitale, Giovanni; Sandrini, Maurizio
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