Streptococcus agalactiae clones infecting humans were selected and fixed through the extensive use of tetracycline
Academic Article
Publication Date:
2014
Short description:
Streptococcus agalactiae clones infecting humans were selected and fixed through the extensive use of tetracycline / Da Cunha, Violette; Davies, Mark R.; Douarre, Pierre-Emmanuel; Rosinski-Chupin, Isabelle; Margarit, Immaculada; Spinali, Sebastien; Perkins, Tim; Lechat, Pierre; Dmytruk, Nicolas; Sauvage, Elisabeth; Ma, Laurence; Romi, Benedetta; Tichit, Magali; Lopez-Sanchez, Maria-José; Descorps-Declere, Stéphane; Souche, Erika; Buchrieser, Carmen; Trieu-Cuot, Patrick; Moszer, Ivan; Clermont, Dominique; Maione, Domenico; Bouchier, Christiane; Mcmillan, David J.; Parkhill, Julian; Telford, John L.; Dougan, Gordan; Walker, Mark J.; Holden, Matthew T. G.; Poyart, Claire; Glaser, Philippe; Melin, Pierette; Decheva, Antoaneta; Petrunov, Bogdan; Kriz, Paula; Berner, Reinhard; Buchele, Anna; Hufnagel, Markus; Kunze, Mirjam; Creti, Roberta; Baldassarri, Lucilla; Orefici, Graziella; Berardi, Alberto; Granger, Javier Rodriguez; Fraile, Manuel De La Rosa; Afshar, Baharak; Efstratiou, Androulla. - In: NATURE COMMUNICATIONS. - ISSN 2041-1723. - 5:1(2014), pp. 1-11. [10.1038/ncomms5544]
abstract:
Streptococcus agalactiae (Group B Streptococcus, GBS) is a commensal of the digestive and genitourinary tracts of humans that emerged as the leading cause of bacterial neonatal infections in Europe and North America during the 1960s. Due to the lack of epidemiological and genomic data, the reasons for this emergence are unknown. Here we show by comparative genome analysis and phylogenetic reconstruction of 229 isolates that the rise of human GBS infections corresponds to the selection and worldwide dissemination of only a few clones. The parallel expansion of the clones is preceded by the insertion of integrative and conjugative elements conferring tetracycline resistance (TcR). Thus, we propose that the use of tetracycline from 1948 onwards led in humans to the complete replacement of a diverse GBS population by only few TcR clones particularly well adapted to their host, causing the observed emergence of GBS diseases in neonates. © 2014 Macmillan Publishers Limited. All rights reserved.
Iris type:
Articolo su rivista
Keywords:
Anti-Bacterial Agents; Base Sequence; Clone Cells; DNA Transposable Elements; Europe; High-Throughput Nucleotide Sequencing; Humans; Molecular Sequence Data; North America; Phylogeny; Polymorphism, Single Nucleotide; Selection, Genetic; Streptococcal Infections; Streptococcus agalactiae; Tetracycline; Tetracycline Resistance; Genes, Bacterial; Genome, Bacterial; Chemistry (all); Biochemistry, Genetics and Molecular Biology (all); Physics and Astronomy (all)
List of contributors:
Da Cunha, Violette; Davies, Mark R.; Douarre, Pierre-Emmanuel; Rosinski-Chupin, Isabelle; Margarit, Immaculada; Spinali, Sebastien; Perkins, Tim; Lechat, Pierre; Dmytruk, Nicolas; Sauvage, Elisabeth; Ma, Laurence; Romi, Benedetta; Tichit, Magali; Lopez-Sanchez, Maria-José; Descorps-Declere, Stéphane; Souche, Erika; Buchrieser, Carmen; Trieu-Cuot, Patrick; Moszer, Ivan; Clermont, Dominique; Maione, Domenico; Bouchier, Christiane; Mcmillan, David J.; Parkhill, Julian; Telford, John L.; Dougan, Gordan; Walker, Mark J.; Holden, Matthew T. G.; Poyart, Claire; Glaser, Philippe; Melin, Pierette; Decheva, Antoaneta; Petrunov, Bogdan; Kriz, Paula; Berner, Reinhard; Buchele, Anna; Hufnagel, Markus; Kunze, Mirjam; Creti, Roberta; Baldassarri, Lucilla; Orefici, Graziella; Berardi, Alberto; Granger, Javier Rodriguez; Fraile, Manuel De La Rosa; Afshar, Baharak; Efstratiou, Androulla
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