Publication Date:
2017
Short description:
LYSYL OXIDASE INHIBITORS / Marais, Richard; Springer, Caroline; NICULESCU-DUVAZ, Dan; Miller, Natalie; Aljarah, Mohammed; Zambon, Alfonso; Leung, Leo; Smithen, Deborah; Brown, Michael; Tang, Haoran. - (2017 Oct 13).
abstract:
This invention relates to compounds useful as lysyl oxidase (LOX) and lysyl oxidase-like (LOXL) family member (LOXL1, LOXL2, LOXL3, LOXL4) inhibitors. In addition there are contemplated pharmaceutical compositions comprising the compounds and the use of the compounds in the treatment of conditions mediated by LOX and LOXL, for example cancer. In particular a LOX inhibitor such as the present compounds may be for use in the treatment of a cancer associated with EGFR. The present invention also contemplates the identification of biomarkers that predict responsiveness to a LOX inhibitor.
Iris type:
Brevetto
List of contributors: