Fast electroanalytical determination of Cannabidiol and Cannabinol in aqueous solution using Sonogel-carbon-PEDOT devices

In this work, we present the first results obtained for the electroanalytical determination of Cannabidiol (CBD), the
major non-psychoactive cannabinoid of Cannabis sativa L. plant, and Cannabinol (CBN). To this purpose, Sonogel-
Carbon-PEDOT material was employed due to the high conductivity provided by poly-(3,4-ethylenedioxythiophene)
(PEDOT) combined with graphite powder. Electrochemical measurements were performed in different aqueous buffered
solutions mixed with acetonitrile or ethanol to improve the solubility of the analyte. In particular, the ethanol/
borate buffer solution 15:85 (v/v) provided a higher electrochemical response of CBD as well as a lower potential
peak value. CBD was assayed in a concentration range from 1.59 to 19.1 μM, obtaining high sensitivity, 421 ± 26.1
μA/mM·cm2 and low detection limit, 0.94 μM. CBN was also assayed, from 1.61 to 25.8 μM, obtaining 588 ± 13.6
μA/mM·cm2 as sensitivity and 1.29 μM as limit of detection. Based on the experimental results, the electroanalytical
method developed represents a tool for the rapid determination of these types of cannabinoids.