Constitutively active receptor mutants as probes for studying the mechanisms underlying G protein-coupled receptor activation
Chapter
Publication Date:
1999
Short description:
Constitutively active receptor mutants as probes for studying the mechanisms underlying G protein-coupled receptor activation / S., C., Fanelli, F., A., S., De Benedetti, P.G. - In: Structure/function analysis of GPCRs / J. WESS EDITOR. - ELETTRONICO. - New York : Wiley, 1999. - ISBN 9780471252283. - pp. 167-183
abstract:
In this chapter, we illustrate a strategy to explore the potential molecular changes correlated with the transition from R to R* using the Gq-coupled alpha1B-AR as model system.
Iris type:
Capitolo/Saggio
Keywords:
GPCRs; adrenergic receptors; computational modeling
List of contributors:
S., Cotecchia; Fanelli, Francesca; A., Scheer; De Benedetti, Pier Giuseppe
Book title:
Structure/function analysis of GPCRs