Publication Date:
2009
Short description:
A novel class of allosteric modulators of AMPA/Kainate receptors / Cannazza, Giuseppe; Krzysztof, Jozwiak; Parenti, Carlo; Braghiroli, Daniela; Carrozzo, Marina Maria; Puja, Giulia; Losi, Gabriele; Baraldi, Mario; Wolfgang, Lindner; Irving W., Wainer. - In: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. - ISSN 0960-894X. - STAMPA. - 19:4(2009), pp. 1254-1257. [10.1016/j.bmcl.2008.12.094]
abstract:
The rapid hydrolysis in vivo of IDRA21 to 2-amino-5-chlorobenzensulfonamide has been demonstrated by microdialysis experiments. The IDRA21 metabolite possess in vitro a biological activity similar to that of IDRA21 itself. Taking 2-amino-5-chlorobenzensulfonamide as lead compound, a novel class of AMPAR positive allosteric modulators has been prepared.
Iris type:
Articolo su rivista
Keywords:
IDRA21; AMPA positive modulators; 2-Amino-5-chlorobenzensulfonamide
List of contributors:
Cannazza, Giuseppe; Krzysztof, Jozwiak; Parenti, Carlo; Braghiroli, Daniela; Carrozzo, Marina Maria; Puja, Giulia; Losi, Gabriele; Baraldi, Mario; Wolfgang, Lindner; Irving W., Wainer
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