Impact of age on cytotoxic-induced ovarian failure in breast cancer treated with adjuvant chemotherapy and triptorelin
Academic Article
Publication Date:
2016
Short description:
Impact of age on cytotoxic-induced ovarian failure in breast cancer treated with adjuvant chemotherapy and triptorelin / Meattini, I., Saieva, C., Meacci, F., Scotti, V., De Luca Cardillo, C., Desideri, I., Baldazzi, V., Mangoni, M., Scoccianti, S., Detti, B., Simontacchi, G., Nori, J., Orzalesi, L., Sanchez, L., Casella, D., Bernini, M., Fambrini, M., Bianchi, S., Livi, L.. - In: FUTURE ONCOLOGY. - ISSN 1479-6694. - 12:5(2016), pp. 625-635. [10.2217/fon.15.357]
abstract:
This study analyzes our single-center, retrospective experience on 63 premenopausal breast cancer patients treated with monthly triptorelin and concomitant chemotherapy.
PATIENTS & METHODS:
Concomitant chemotherapy and triptorelin were adopted as part of premature ovarian failure prevention strategy.
RESULTS:
Age at diagnosis was the main factor influencing fertility preservation (p = 0.002). Compared with patients aged 41-45 years, the probability of menses resumption was almost threefold than for women aged 35-40 years, and significantly higher for women aged <35 years (hazard ratio: 9.0; p = 0.0001). The cumulative proportion among patients who resumed menses was 33.3% at 6 months, 75% at 12 months and 87.5% at 24 months. Seven patients attempted pregnancy, and five (71%) obtained healthy deliveries.
CONCLUSION:
We observed an acceptable rate of fertility preservation. Age at diagnosis influences fertility preservation.
PATIENTS & METHODS:
Concomitant chemotherapy and triptorelin were adopted as part of premature ovarian failure prevention strategy.
RESULTS:
Age at diagnosis was the main factor influencing fertility preservation (p = 0.002). Compared with patients aged 41-45 years, the probability of menses resumption was almost threefold than for women aged 35-40 years, and significantly higher for women aged <35 years (hazard ratio: 9.0; p = 0.0001). The cumulative proportion among patients who resumed menses was 33.3% at 6 months, 75% at 12 months and 87.5% at 24 months. Seven patients attempted pregnancy, and five (71%) obtained healthy deliveries.
CONCLUSION:
We observed an acceptable rate of fertility preservation. Age at diagnosis influences fertility preservation.
Iris type:
Articolo su rivista
Keywords:
adjuvant treatment; breast cancer; concomitant chemotherapy; fertility preservation; GnRH analogs; premature ovarian failure; triptorelin; Oncology; Cancer Research
List of contributors:
Meattini, Icro; Saieva, Calogero; Meacci, Fiammetta; Scotti, Vieri; De Luca Cardillo, Carla; Desideri, Isacco; Baldazzi, Valentina; Mangoni, Monica; Scoccianti, Silvia; Detti, Beatrice; Simontacchi, Gabriele; Nori, Jacopo; Orzalesi, Lorenzo; Sanchez, Luis; Casella, Donato; Bernini, Marco; Fambrini, Massimiliano; Bianchi, Simonetta; Livi, Lorenzo
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