Non-monotonic current-to-rate response function in a novel integrate-and-fire model neuron

A novel integrate-and-fire model neuron is proposed to account for a non-monotonic f-I response function, as experimentally observed. As opposed to classical forms of adaptation, the present integrate- and-fire model the spike-emission process incorporates a state - dependent inactivation that makes the probability of emitting a spike decreasing as a function of the mean depolarization level instead of the mean firing rate. © Springer-Verlag Berlin Heidelberg 2002.