Bioactive phospho-silicate glasses containing CaF2: bioactivity test in simulated body fluids and behaviour towards osteoblast cells

In this work it is reported a study, in vitro (DMEM), of some potentially bioactive glasses based on the composition of Bioglass® 45S5 bioactive glass, in which CaF2 substitutes alternatively CaO and Na2O. Using a multi-techniques investigation, it is possible to explain in detail the glasses degradatation and the mechanism of formation of an apatitic layer between inorganic material and biological medium. The behaviour of doped glasses is differs from that proposed by Hench for Bioglass® 45S5 bioactive glass, however, these doped glasses have capability of developing bio-activity.A preliminary cellular test is also performed in view of a potential clinical application