Effect of roflumilast on exacerbations in patients with severe chronic obstructive pulmonary disease uncontrolled by combination therapy (REACT): a multicentre randomised controlled trial
Academic Article
Publication Date:
2015
Short description:
Effect of roflumilast on exacerbations in patients with severe chronic obstructive pulmonary disease uncontrolled by combination therapy (REACT): a multicentre randomised controlled trial / Martinez, Fernando; Calverley, Peter; Goehring, Udo Michael; Brose, Manja; Fabbri, Leonardo; Rabe, Klaus. - In: THE LANCET. - ISSN 0140-6736. - STAMPA. - 385:9971(2015), pp. 857-866. [10.1016/S0140-6736(14)62410-7]
abstract:
Roflumilast reduces exacerbations in patients with severe chronic obstructive pulmonary disease. Its effect in patients using fixed combinations of inhaled corticosteroids and longacting β2 agonists is unknown. We postulated that roflumilast would reduce exacerbations in patients with severe chronic obstructive pulmonary disease at risk for exacerbations, even in combination with inhaled corticosteroid and longacting β2 agonist treatment.
Iris type:
Articolo su rivista
List of contributors:
Martinez, Fernando; Calverley, Peter; Goehring, Udo Michael; Brose, Manja; Fabbri, Leonardo; Rabe, Klaus
Published in: