EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Journal

Identifier:

E060692

ISSN:

0223-5234

Overview

Research Outputs (47)

1,3-Dioxane as a scaffold for potent and selective 5-HT1AR agonist with in-vivo anxiolytic, anti-depressant and anti-nociceptive activity

Academic Article

1,3-Dioxolane-Based Ligands Incorporating a Lactam or Imide moiety: Structure-Affinity/Activity Relationship at alpha1–Adrenoceptor subtypes and at 5-HT1A Receptors

Academic Article

2-[N-Alkyl(R-phenyl)-aminomethyl]-3-phenyl-7-trifluoromethylquinoxalines as anticancer agents inhibitors of folate enzymes

Academic Article

7-Hydroxy-2-substituted-4-H-1-benzopyran-4-one derivatives as aldose reductase inhibitors: a SAR study

Academic Article

A rational approach to the design of flavones as xanthine oxidase inhibitors

Academic Article

Amphiphilic ion pairs of tobramycin with lipoamino acids

Academic Article

Application of a post-docking procedure based on MM-PBSA and MM-GBSA on single and multiple protein conformations

Academic Article

Aryl thiosemicarbazones for the treatment of trypanosomatidic infections

Academic Article

Bifunctional compounds targeting both D2 and non-α7 nACh receptors: Design, synthesis and pharmacological characterization

Academic Article

Computational analysis of ligand recognition sites of homo- andheteropentameric 5-HT3 receptors

Academic Article

Correlation hetween adrenergic alpha-receptorantagonists of tetramine disulfidesand benzodioxanes classes

Academic Article

Crassiflorone derivatives that inhibit Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase (TbGAPDH) and Trypanosoma cruzi trypanothione reductase (TcTR) and display trypanocidal activity

Academic Article

Discovery and development of novel salicylate synthase (MbtI) furanic inhibitors as antitubercular agents

Academic Article

Discovery of a benzothiophene-flavonol halting miltefosine and antimonial drug resistance in Leishmania parasites through the application of medicinal chemistry, screening and genomics

Academic Article

Discovery of potent pyrrolo-pyrimidine and purine HDAC inhibitors for the treatment of advanced prostate cancer

Academic Article

Host dihydrofolate reductase (DHFR)-directed cycloguanil analogues endowed with activity against influenza virus and respiratory syncytial virus

Academic Article

IDENTIFICATION OF PYRAZOLO-PIPERIDINONE DERIVATIVES TARGETING YAP-TEAD INTERFACE 3 AS ANTICANCER AGENTS THROUGH INTEGRATED VIRTUAL SCREENING AND MASS SPECTROMETRY PROTEOMICS

Academic Article

Identification of 4-amino-2-Pyridones as new potent PCSK9 inhibitors: From phenotypic hit discovery to in vivo tolerability

Academic Article

Identification of a 2,4-diaminopyrimidine scaffold targeting Trypanosoma brucei pteridine reductase 1 from the LIBRA compound library screening campaign

Academic Article

Identification of non-ATP-competitive α-carboline inhibitors of the anaplastic lymphoma kinase

Academic Article

Methoxylated 2'-hydroxychalcones as antiparasitic hit compounds

Academic Article

Molecular properties of the adrenergic alpha-receptor6. - Optimum carbon chain-length between the inner nitrogenand the sulfur of tetramine disulfides

Academic Article

Molecular properties of the adrenergic alpha-receptors.4.Topographical and structural differences betweentissue-specific binding sites as revealedby benextramine and analogues.

Academic Article

Molecular requirements of the active sites of thecholinergic receptors XVII. 1,3-oxathiolane nucleus as a carrier of the active moeties

Academic Article

Naphthalimido Derivatives as Antifolate Thymidylate Synthase Inhibitors

Academic Article

New dimeric cGMP analogues reduce proliferation in three colon cancer cell lines

Academic Article

Preparation and optimization of PIT solid lipid nanoparticles via statistical factorial design.

Academic Article

Relationship between quantum-chemical descriptors of proton dissociation and experimental acidity contants of variously hydroxylated coumarins. Identification of the biologically active species for xanthine oxidase inhibition

Academic Article

Resolution of the potent α1-adrenoreceptor antagonist 2-[[[2-(2,6-dimethoxyphenoxy)ethyl]amino]methyl]-1,4-benzoxathian (benoxathian)

Academic Article

Scouting new sigma receptor ligands: Synthesis, pharmacological evaluation and molecular modeling of 1,3-dioxolane-based structures and derivatives

Academic Article

Structural requirements for adrenergic alpha-receptorcovalent occupancy by chiral tetramine disulfides

Academic Article

Structure-affinity/activity relationships of 1,4-dioxa-spiro[4.5]decane based ligands at α1 and 5-HT1A receptors

Academic Article

Structure-guided optimization of 3-hydroxybenzoisoxazole derivatives as inhibitors of Aldo-keto reductase 1C3 (AKR1C3) to target prostate cancer

Academic Article

Synthesis and activity of a new series of chalcones as aldose reductase inhibitors

Academic Article

Synthesis and alpha blocking activity of some analogues of idazoxan

Academic Article

Synthesis and alpha-blocl«ing activity of some cyclicand opened analogues of WB 4101 (-)

Academic Article

Synthesis and antiplatelet activity of thioaryloxyacids analogues of clofibric acid

Academic Article

Synthesis and structureeactivity relationship studies in serotonin 5-HT4 receptor ligands based on a benzo[de][2,6]naphthridine scaffold

Academic Article

Synthesis of N-(5,7-diamino-3-phenyl-quinoxalin-2-yl)-3,4,5-substituted anilines and N-[4[(5,7-diamino-3-phenylquinoxalin-2-yl)amino]benzoyl]-l-glutamic acid diethyl ester: evaluation of in vitro anti-cancer and anti-folate activities

Academic Article

Synthesis, biological evaluation and molecular modeling of 1-oxa-4-thiaspiro- and 1,4-dithiaspiro[4.5]decane derivatives as potent and selective 5-HT1A receptor agonists

Academic Article

Synthesis, biological evaluation and molecular modeling of novel azaspiro dihydrotriazines as influenza virus inhibitors targeting the host factor dihydrofolate reductase (DHFR)

Academic Article

Synthesis, characterization and in vitro evaluation of amphiphilic ion pairs of erythromycin and kanamycin antibiotics with liposaccharides

Academic Article

Synthesis, characterization, crystallographic analysis, antifungal and genotoxic properties of some 1-methyl-1H-imidazoles

Academic Article

Synthesis, chemical and biological studies on new Fe3þ-glycosilated b-diketo complexes for the treatment of iron deficiency

Academic Article

The discovery of aryl-2-nitroethyl triamino pyrimidines as anti-Trypanosoma brucei agents

Academic Article

Theoretical and experimental study of flavones as inhibitors of xanthine oxidase

Academic Article

X-ray crystal structures of Enterococcus faecalis thymidylate synthase with folate binding site inhibitors

Academic Article

No Results Found

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Overview

Research Outputs (47)