In recent years, we have witnessed the emergence of DNA nanotechnology that enables self-assembly of some of the largest and most complex functional molecular systems to date. Simultaneously, RNA plays a pivotal role in nanomedical advancements, notably in the development of Covid-19 vaccines. Moreover, utilising deep learning to address the protein prediction challenge paves the way for de novo protein design in the realm of protein nanotechnology. BioHYBRITE is designed as an innovative and pioneering training network, with the unique vision of developing the next-generation of biomolecular systems based on integrated hybrid DNA:RNA:Protein nanotechnology. BioHYBRITE brings together leading European research groups for combining all sequence-based biomolecules into a unified bottom-up nanobiotechnology. The consortium will collectively build modular platforms with a range of novel functions for molecular sensing, information processing and actuation. Thereby the collaboration
Project In recent years, we have witnessed the emergence of DNA nanotechnology that enables self-assembly of some of the largest and
most complex functional molecular systems to date. Simultaneously, RNA plays a pivotal role in nanomedical advancements, notably
in the development of Covid-19 vaccines. Moreover, utilising deep learning to address the protein prediction challenge paves the way
for de novo protein design in the realm of protein nanotechnology. BioHYBRITE is designed as an innovative and pioneering training
network, with the unique vision of developing the next-generation of biomolecular systems based on integrated hybrid
DNA:RNA:Protein nanotechnology. BioHYBRITE brings together leading European research groups for combining all sequence-based
biomolecules into a unified bottom-up nanobiotechnology. The consortium will collectively build modular platforms with a range of
novel functions for molecular sensing, information processing and actuation. Thereby the collaboration synergizes a unique toolset of
theoretical and experimental methods for designing and understanding the hybrid systems including state-of-the-art single-molecule
and superresolution technology. The outcome will be a new generation of young experts in the development of smart, selfassembling,
hybrid nano-devices that detect and act in complex biomolecular systems and will form the basis of a future
nanomedicine based on active molecular systems. The doctoral candidates will be trained in all aspects for programmed design of
hybrid bottom-up nanostructures, their characterization and use for decoding and interacting with biomolecular systems, thereby
fully benefiting from the synergies of the different partners’ competences. The innovative and applied focus is supported by the
involvement of pioneering industrial partners providing complementary skills training as well as intersectoral exchange of the
doctoral candidates with a potential high impact in future exploitations.