Circulating Mitochondrial DNA and Lipopolysaccharide-Binding Protein but Not Bacterial DNA Are Increased in Acute Human Immunodeficiency Virus Infection.

Articolo
Data di Pubblicazione:
2020
Citazione:
Circulating Mitochondrial DNA and Lipopolysaccharide-Binding Protein but Not Bacterial DNA Are Increased in Acute Human Immunodeficiency Virus Infection / Nasi, M., Pecorini, S., De Biasi, S., Digaetano, M., Chester, J., Aramini, B., Lo Tartaro, D., Pinti, M., De Gaetano, A., Gibellini, L., Mattioli, A.V., Mussini, C., Cossarizza, A.. - In: AIDS RESEARCH AND HUMAN RETROVIRUSES. - ISSN 0889-2229. - 36:10(2020), pp. 817-820. [10.1089/aid.2020.0098]
Abstract:
Microbial translocation has been suggested as a major driver of chronic immune activation HIV infection. Thus, we compared the extent of microbial translocation in patients with acute HIV infection and patients followed after CD4-guided structured treatment interruption (STI) by measuring different circulating markers: (1) lipopolysaccharide (LPS)-binding protein (LBP), (2) bacterial DNA, (3) soluble CD14 (sCD14), and (4) mitochondrial DNA (mtDNA). Bacterial DNA and sCD14 levels were similar in all groups. Patients in acute phase showed higher levels of LBP and mtDNA. In STI, we found a positive correlation between the percentage of CD8+ T cells and bacterial DNA levels. Considering all patients, LBP was positively correlated with the percentage and the absolute count of CD8+ T cells, and with mtDNA stressing the importance of mitochondrial products in sustaining chronic immune activation.
Tipologia CRIS:
Articolo su rivista
Keywords:
acute HIV infection; bacterial DNA; circulating mitochondrial DNA; droplet digital PCR; LPS-binding protein; microbial translocation;
Elenco autori:
Autori di Ateneo:
Link alla scheda completa:
https://iris.unimore.it/handle/11380/1208253
Pubblicato in:
AIDS RESEARCH AND HUMAN RETROVIRUSES
Journal