Design and performance of an ophthalmic instrument for dynamic light scattering and fluorescence measurements in ocular tissues

The paper describes an ophthalmic instrument designed to perform in-vivo dynamic light scattering and autofluorescence measurements on ocular tissues. We modified a commercial scanning ocular fluorometer, to include both techniques in the same scanning unit. The resulting optical system provides both dynamic light scattering and autofluorescence measurements from the same ocular volume, which can be located in each section of the ocular axis from the cornea to the retina. In this paper, the instrument is described and in-vitro/in-vivo measurements are presented.