SILENT STIMULATION OF CONES: A COMPARISON BETWEEN THE ERG AND PLR RESPONSES

The Electroretinogram measures the overall electrical activity of the retina in response to light stimulation, while the dynamics of Pupillary Light Reflex reveal information about how the visual pathway innervates the iris muscles in response to such stimuli. By simultaneously evaluating PLR and ERG responses, a deeper understanding of both image-forming and non-image-forming mechanisms of the human visual system can be gained. Additionally, ERG and PLR responses to bursts of light are contributed by all primary classes of photoreceptors, including rods, (L-M-S) cones, and intrinsically photosensitive ganglion cells (ipRGCs). This study presents and tests a low-cost, Maxwellian view-based optical setup that can be used to acquire synchronous PLR and ERG recordings with silent stimulation techniques on cones photoreceptors in human subjects.