The transition from pubertal development to postmenopause discloses a gonadotropin-releasing hormone-independent mechanism regulating follicle-stimulating hormone release

The reproductive function is tightly dependent on gonadotropin secretion and the optimal activity of the hypothalamus-pituitary axis. This study discusses evidence that supports the possible existence of a GnRH-independent modulator of FSH secretion in humans. Stich a hypothesis has been consistently reported in several experimental animals. To test the hypothesis specific times during the physiological development and activity of the hypothalamus-pituitary axis have been evaluated under the use of drugs acting directly on hypothalamic GnRH-secreting neurons, such as GnRH agonists. The possible presence also in humans of such an independent FSH stimulator might be important for the understanding of anovulation and infertility.