GROOMING AND STRETCHING-YAWNING - 2 BEHAVIORAL POINTERS OF D2 DOPAMINE RECEPTOR AGONISTIC EFFECT

A typical stretching-yaning (SY) syndromehas been described to be produce by D2 agonists and D1/D2 agonists when administered at doses incapable of eliciting a marked degree of stereotyped behaviour. Grooming has been reported to be antagonized by some D2 antagonists but stimulated by D1 agonist. Our results show that grooming and SY syndrome, contemporaneous detected, are sensitive behavioural pointers of the D2 selective affinity of the compounds.