Extracellular vesicles derived from mesenchymal cells: Perspective treatment for cutaneous wound healing in pediatrics

Articolo
Data di Pubblicazione:
2018
Citazione:
Extracellular vesicles derived from mesenchymal cells: Perspective treatment for cutaneous wound healing in pediatrics / Pelizzo, G., Avanzini, M.A., Icaro Cornaglia, A., De Silvestri, A., Mantelli, M., Travaglino, P., Croce, S., Romano, P., Avolio, L., Iacob, G., Dominici, M., Calcaterra, V.. - In: REGENERATIVE MEDICINE. - ISSN 1746-0751. - 13:4(2018), pp. 385-394. [10.2217/rme-2018-0001]
Abstract:
Aim: We evaluated the effects of the intradermal injection of extracellular vesicles (EVs) derived from adipose stem cells (ASC-EVs) and bone marrow cells (BM-EVs) in an experimental cutaneous wound repair model. Methods: Mesenchymal stem cells (MSCs) were in vitro expanded from adipose (ASC) or BM tissues (BM-MSC) of rabbits. EVs were separated from the supernatants of confluent ASC and BM-MSCs. Two skin wounds were induced in each animal and treated with MSC or EV injections. Histological examination was performed postinoculation. Results: EV-treated wounds exhibited a better restoration compared with the counterpart MSC treatment. ASC-EV-treated wounds were significantly better than BM-EVs (p = 0.036). Conclusion: EV topical inoculation provides restored architecture during cutaneous wound healing and represents a promising solution for regenerative medicine in children.
Tipologia CRIS:
Articolo su rivista
Keywords:
animal model; children; cutaneous wound repair; extracellular vesicles; mesenchymal stem cells; Adipose Tissue; Animals; Bone Marrow Cells; Cell-Derived Microparticles; Female; Humans; Mesenchymal Stem Cells; Rabbits; Wounds and Injuries; Wound Healing; Biomedical Engineering; Embryology
Elenco autori:
Autori di Ateneo:
Link alla scheda completa:
https://iris.unimore.it/handle/11380/1168921
Pubblicato in:
REGENERATIVE MEDICINE
Journal