Bone marrow derived mesenchymal stem/stromal cells transduced with full length human TRAIL repress the growth of rhabdomyosarcoma cells in vitro
Articolo
Data di Pubblicazione:
2011
Citazione:
Bone marrow derived mesenchymal stem/stromal cells transduced with full length human TRAIL repress the growth of rhabdomyosarcoma cells in vitro / Barti-Juhasz, H.; Mihalik, R.; Nagy, K.; Grisendi, G.; Dominici, M.; Petak, I.. - In: HAEMATOLOGICA. - ISSN 0390-6078. - ELETTRONICO. - 96:3(2011), pp. 21-22. [10.3324/haematol.2010.036822]
Abstract:
Our results with BM-MSCs together with the results ofKuci et al. with CIK cells1 emphasize that cell mediateddelivery of TRAIL to metastatic RMS tumor sites can bea useful approach in RMS therapy. Targeted delivery ofTRAIL to tumors may allow systemic exposure ofpatients to drugs (e.g. the proteasome inhibitor bortezomib)that may overcome resistance for TRAIL-inducedapoptosis in RMS cells.
Tipologia CRIS:
Articolo su rivista
Keywords:
TRAIL; rhabdomyosarcoma; mesenchymal stem/stromal cell; Bone Marrow Cells; Cell Count; Cell Line, Tumor; Coculture Techniques; Enzyme-Linked Immunosorbent Assay; Gene Expression; Growth Inhibitors; Humans; Mesenchymal Stem Cells; Molecular Targeted Therapy; Plasmids; Rhabdomyosarcoma; Stromal Cells; TNF-Related Apoptosis-Inducing Ligand; Transduction, Genetic
Elenco autori:
Barti-Juhasz, H.; Mihalik, R.; Nagy, K.; Grisendi, G.; Dominici, M.; Petak, I.
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