Hunting the risk NPY and ACE Polymorphisms as predictors of cardiovascular diseases: case report and review of the literature
Capitolo di libro
Data di Pubblicazione:
2014
Citazione:
Hunting the risk NPY and ACE Polymorphisms as predictors of cardiovascular diseases: case report and review of the literature / Lo Vasco, Vincenza Rita; Businaro, R; Massoni, F; Borghini, G; Corsi, M; Simeone, C; Ricci, S.. - (2014), pp. 1-6.
Abstract:
Many research efforts were addressed to identify individuals at high risk for multifactorial diseases, such
as cardiovascular alterations and related diseases. Great interest was paid to investigate the genetic liability in
multifactorial illnesses. The prognosis of high-risk patients might be greatly ameliorated using genetic predisposition
risk factors, such as the polymorphisms of neuropeptide Y (NPY) and Angiotensin converting enzyme (ACE) genes.
Epidemiologic results suggest that selected polymorphisms of both NPY and ACE might be helpful to improve
the evaluation of patients, offering a powerful prognostic tool and paving the way to novel molecular therapeutic
strategies.
We present a case report of a male, sudden-death from myocardial infarction, presenting with left ventricular
hypertrophy. The patient carried polymorphisms of ACE and NPY genes, respectively ACE genotype ID and NPY
genotype T-399C, actually considered as risk factors.
as cardiovascular alterations and related diseases. Great interest was paid to investigate the genetic liability in
multifactorial illnesses. The prognosis of high-risk patients might be greatly ameliorated using genetic predisposition
risk factors, such as the polymorphisms of neuropeptide Y (NPY) and Angiotensin converting enzyme (ACE) genes.
Epidemiologic results suggest that selected polymorphisms of both NPY and ACE might be helpful to improve
the evaluation of patients, offering a powerful prognostic tool and paving the way to novel molecular therapeutic
strategies.
We present a case report of a male, sudden-death from myocardial infarction, presenting with left ventricular
hypertrophy. The patient carried polymorphisms of ACE and NPY genes, respectively ACE genotype ID and NPY
genotype T-399C, actually considered as risk factors.
Tipologia CRIS:
Capitolo/Saggio
Keywords:
ACE; NPY; Polymorphisms; Risk factor; Atherosclerosis; Cardiovascular disease; Left ventricular hypertrophy
Elenco autori:
Lo Vasco, Vincenza Rita; Businaro, R; Massoni, F; Borghini, G; Corsi, M; Simeone, C; Ricci, S.
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Titolo del libro:
Internal Medicine Case studies