Interictal and ictal EEG-SPECT correlations in a patient with partial seizures and mesial temporal sclerosis

We studied a 26 year-old patient with partial seizures and right mesial temporal sclerosis by means of computerized video-EEG monitoring and SPECT. Ictal seizures semiology was compatible with mesial temporal seizures. Dipole modeling of interictal and ictal paroxysmal activities and peri-postictal SPECT were consistent with involvement of the anterior-middle portion of the right temporal lobe, in accordance with MRI findings. These results show the usefulness of a multimodal approach, combining neuroimaging and neurophysiological techniques to obtain non-invasive information on the epileptogenic area.