Senescence and immune system: The example of centenarians

Healthy centenarians are the best example of successful ageing, as they have escaped the major age-associated diseases, and most of them are in good mental and physical condition. In this review, it is discussed how the study of their immune systems reveals that several immune parameters are still well conserved, suggesting that a complex remodelling of most immune parameters occurs with age, rather than a unidirectional deterioration.