Acetamidomethaneboronic acids bearing the R1 side chains of beta-lactams as inhibitors of beta-lactamase enzymes
Brevetto
Citazione:
Acetamidomethaneboronic acids bearing the R1 side chains of beta-lactams as inhibitors of beta-lactamase enzymes / L. C., Blaszczak; Caselli, Emilia; Prati, Fabio; B. K., Shoichet.
Abstract:
The invention provides a method of treating a .beta.-lactam-antibiotic-resistant bacterial infection with a combination of a .beta.-lactamanalog (acylaminomethaneboronic acid deriv.). The invention also provides a method of inhibiting a .beta.-lactamase comprising contacting the .beta.-lactamase with a .beta.-lactamanalog. Finally, the invention provides compds. which are .beta.-lactamanalogs and compns. contg. .beta.-lactam analogs.
Tipologia CRIS:
Brevetto
Keywords:
bacyterial infections; antibiotic resistance; beta-lactamases; inhibitors; boronic acids; transition state analog; stereoselective synthesis.
Elenco autori:
L. C., Blaszczak; Caselli, Emilia; Prati, Fabio; B. K., Shoichet
Link alla scheda completa: