Hyaluronic acid in obstetrics: role in Physiological Pregnancy

Pregnancy is a physiologically fine-balanced condition, characterized by radical hormonal and physical changes necessary for successful blastocyst implantation, optimal embryo development and safe birth. During gestation, several biological modifications are adopted by maternal body to accept the fetus (e.g., immune tolerance). In this context, Hyaluronic Acid (HA) is an interesting molecule, seemingly involved in many steps of the process, with a pivotal role in ovulation, fertilization, blastocyst implantation, inhibition of uterine contraction, immunomodulation of T cells or labour-related cervical modifications.