Data di Pubblicazione:
2018
Citazione:
Non-O blood group and outcomes of in vitro fertilization / Di Nisio, M., Ponzano, A., Tiboni, G.M., Guglielmi, M.D., Rutjes, A.W.S., Porreca, E.. - In: JOURNAL OF ASSISTED REPRODUCTION AND GENETICS. - ISSN 1058-0468. - 35:7(2018), pp. 1289-1294. [10.1007/s10815-018-1185-6]
Abstract:
PURPOSE: Retrospective and cross-sectional studies suggested that non-O blood
group may be associated with failures of in vitro fertilization (IVF), but data
remain controversial. The aim of this observational cohort study was to
prospectively evaluate the effect of non-O blood type on clinical outcomes of
IVF.
METHODS: Women < 40 years who underwent IVF and had ABO blood type recorded as
part of the routine workup were eligible. The primary study outcome was live
birth. Secondary outcomes included spontaneous abortion, positive pregnancy test,
and clinical pregnancy.
RESULTS: A total of 497 women with a mean age of 34.6 (standard deviation 3.2)
years were included. The mean number of embryos transferred was 2.3 (standard
deviation 0.6). The most common ABO blood types were O (n = 213, 42.9%) and A
(n = 203, 40.8%), while 63 (12.7%) and 18 (3.6%) women had the B and AB blood
types, respectively. Differences in live birth (21.8 vs. 24.3%, odds ratio [OR]
1.17; 95% confidence intervals [CI], 0.76 to 1.78), positive pregnancy test (37.9
vs. 36.6%, OR 0.96; 95% CI, 0.66 to 1.38), clinical pregnancy (35.1 vs. 33.8%, OR
0.95; 95% CI, 0.66 to 1.39), and spontaneous abortion (12.3 vs. 9.2%, OR 0.72;
95% CI, 0.41 to 1.29) between women with O and non-O blood type were not
statistically significant.
CONCLUSIONS: In a prospective cohort study, we confirmed the lack of a
significant association between non-O blood type and clinical outcomes of IVF.
Further studies are needed to clarify whether non-O blood group has any
prognostic relevance in women undergoing IVF.
group may be associated with failures of in vitro fertilization (IVF), but data
remain controversial. The aim of this observational cohort study was to
prospectively evaluate the effect of non-O blood type on clinical outcomes of
IVF.
METHODS: Women < 40 years who underwent IVF and had ABO blood type recorded as
part of the routine workup were eligible. The primary study outcome was live
birth. Secondary outcomes included spontaneous abortion, positive pregnancy test,
and clinical pregnancy.
RESULTS: A total of 497 women with a mean age of 34.6 (standard deviation 3.2)
years were included. The mean number of embryos transferred was 2.3 (standard
deviation 0.6). The most common ABO blood types were O (n = 213, 42.9%) and A
(n = 203, 40.8%), while 63 (12.7%) and 18 (3.6%) women had the B and AB blood
types, respectively. Differences in live birth (21.8 vs. 24.3%, odds ratio [OR]
1.17; 95% confidence intervals [CI], 0.76 to 1.78), positive pregnancy test (37.9
vs. 36.6%, OR 0.96; 95% CI, 0.66 to 1.38), clinical pregnancy (35.1 vs. 33.8%, OR
0.95; 95% CI, 0.66 to 1.39), and spontaneous abortion (12.3 vs. 9.2%, OR 0.72;
95% CI, 0.41 to 1.29) between women with O and non-O blood type were not
statistically significant.
CONCLUSIONS: In a prospective cohort study, we confirmed the lack of a
significant association between non-O blood type and clinical outcomes of IVF.
Further studies are needed to clarify whether non-O blood group has any
prognostic relevance in women undergoing IVF.
Tipologia CRIS:
Articolo su rivista
Keywords:
ABO blood type; Assisted reproductive techniques; Thrombophilia; Reproductive Medicine; Genetics; Obstetrics and Gynecology; Developmental Biology; Genetics (clinical)
Elenco autori:
Di Nisio, M.; Ponzano, A.; Tiboni, G. M.; Guglielmi, Maria Domenica; Rutjes, A. W. S.; Porreca, E.
Link alla scheda completa:
Pubblicato in: