Assesment of serum IGF-I concentrations in the diagnosis of isolated childhood-onset GH deficiency: A proposal of the Italian Society for Pediatric Endocrinology and Diabetes (SIEDP/ISPED)
Articolo
Data di Pubblicazione:
2006
Citazione:
Assesment of serum IGF-I concentrations in the diagnosis of isolated childhood-onset GH deficiency: A proposal of the Italian Society for Pediatric Endocrinology and Diabetes (SIEDP/ISPED) / Federico, G.; Street, M. E.; Maghnie, M.; Caruso-Nicoletti, M.; Loche, S.; Bertelloni, S.; Cianfarani, S.; Cicognani, A.; Cesaretti, G.; Lorini, R.; Meschi, F.; De Sanctis, V.; Aimarretti, G.; Antoniazzi, F.; Arrigo, T.; Bellone, J.; Bellone, S.; Bertalloni, S.; Bozzola, M.; Buzi, F.; Cappa, M.; Cistemino, M.; De Luca, F.; Del Vecchio, M.; Galluzzi, F.; Germani, D.; Ghirri, P.; Ghizzoni, L.; Greggio, N. A.; Iughetti, L.; Losi, S.; Luciano, A.; Maffeis, C.; Modestini, E.; Pirazzoli, P.; Pozzobon, G.; Predieri, B.; Rusconi, R.; Slerno, M. C.; Salvatoni, A.; Scirè, G.; Scommegna, S.; Spadoni, G. L.; Sposito, M.; Wasniewska, M.; Zampolli, M.; Zucchini, S.. - In: JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION. - ISSN 0391-4097. - STAMPA. - 29:8(2006), pp. 732-737. [10.1007/BF03344184]
Abstract:
The diagnosis of GH deficiency (GHD) is based on the measurement of peak GH responses to pharmacological stimuli. Pharmacological stimuli, however, lack precision, accuracy, are not reproducible, are invasive, non-physiological and some may even be hazardous. Furthermore, different GH commercial assays used to measure GH in serum yield results that may differ considerably. In contrast to GH, IGF-I can be measured on a single, randomly-obtained blood sample. A review of the available data indicates that IGF-I measurement in the diagnosis of childhood-onset isolated GHD has a specificity of up to 100%, with a sensitivity ranging from about 70 to 90%. We suggest an algorithm in which circulating levels of IGF-I together with the evaluation of auxological data, such as growth rate and growth, may be used to assess the likelihood of GHD in pre-pubertal children.
Tipologia CRIS:
Articolo su rivista
Keywords:
GH deficiency; GH secretion; IGF-I; IGF-II; IGF-binding protein-3; acid-labile subunit
Elenco autori:
Federico, G.; Street, M. E.; Maghnie, M.; Caruso-Nicoletti, M.; Loche, S.; Bertelloni, S.; Cianfarani, S.; Cicognani, A.; Cesaretti, G.; Lorini, R.; Meschi, F.; De Sanctis, V.; Aimarretti, G.; Antoniazzi, F.; Arrigo, T.; Bellone, J.; Bellone, S.; Bertalloni, S.; Bozzola, M.; Buzi, F.; Cappa, M.; Cistemino, M.; De Luca, F.; Del Vecchio, M.; Galluzzi, F.; Germani, D.; Ghirri, P.; Ghizzoni, L.; Greggio, N. A.; Iughetti, L.; Losi, S.; Luciano, A.; Maffeis, C.; Modestini, E.; Pirazzoli, P.; Pozzobon, G.; Predieri, B.; Rusconi, R.; Slerno, M. C.; Salvatoni, A.; Scirè, G.; Scommegna, S.; Spadoni, G. L.; Sposito, M.; Wasniewska, M.; Zampolli, M.; Zucchini, S.
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