Erythema multiforme associated with contact sensitization. Description of 6 clinical cases

Allergic contact dermatitis generally presents itself as an eczematous eruption. However, some allergens, such as plants, exotic woods, topical medications and chemicals have been reported as causing an erythema multiforme-like eruption. We describe 6 patients, 4 women and 2 men ranging from 28 to 66 years. They showed erythematous urticarial papules, plaques and target-lesions similar to the manifestations previously reported as "erythema multiforme-like eruption". On the basis of the positive epicutaneous tests, the aetiological agents of these reactions are presumed to be Idoxuridine, textile dyes, deodorants, paraphenylenediamine and pyrrolnitrin. The clinical pattern, the histopathological features and the pathogenesis are discussed. Finally, the clinical and anamnestic criteria indicating the opportunity of performing patch tests in patients showing an atypical erythema multiforme are suggested.