Effects of some central nervous system drugs upon mitochondrial morphology in pathogenic and non-pathogenic Candida species.

We have reported that six nervous system drugs determined inhibition of the vegetative reproduction of Saccharomyces cerevisiae, Candida utilis, Candida albicans e Candida tropicalis cultured in presence of glucose as carbon source. Chlorpheniramine and chlorpromazine are effective inhibitors of the vegetative reproduction of both pathogenic and non pathogenic strains, had also some effects upon the biogenesis or the assembly of the inner mitochondrial membrane system without any observable effect upon other subcellular structures.